Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1704207 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
170420717062342028Membrane protein containing HD superfamily hydrolase domainQuickGO ontologyBLASTP
170628817074961209stage IV sporulation protein putativeQuickGO ontologyBLASTP
17074931707780288hypothetical proteinBLASTP
17079311708374444GatBYqey family proteinQuickGO ontologyBLASTP
17084021708584183ribosomal protein S21QuickGO ontologyBLASTP
17087241709068345Hit family proteinQuickGO ontologyBLASTP
170915517104561302MiaB-like tRNA modifying enzymeQuickGO ontologyBLASTP
17104561711211756conserved hypothetical protein TIGR00046QuickGO ontologyBLASTP
17112271712165939ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
171229217134221131chaperone protein DnaJQuickGO ontologyBLASTP
171352117153741854chaperone protein DnaKQuickGO ontologyBLASTP
17154301716047618co-chaperone GrpEQuickGO ontologyBLASTP
171605917171231065heat-inducible transcription repressor HrcAQuickGO ontologyBLASTP
171731817184451128oxygen-independent coproporphyrinogen III oxidase putativeQuickGO ontologyBLASTP
171847317202781806GTP-binding protein LepAQuickGO ontologyBLASTP
17203761720771396hypothetical protein
172082317219291107stage II sporulation protein PQuickGO ontologyBLASTP
17219931722967975Germination protease precursor Spore protease GPRendopeptidase Germination proteinaseQuickGO ontologyBLASTP
17231651723431267ribosomal protein S20QuickGO ontologyBLASTP
172350117245231023hypothetical proteinBLASTP