Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:37456 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
374563753075tRNA-GluQuickGO ontologyBLASTP
375443761976tRNA-ValQuickGO ontologyBLASTP
376323770877tRNA-AspQuickGO ontologyBLASTP
377143778976tRNA-ThrQuickGO ontology
3794638938993DNA replication protein DnaC putativeQuickGO ontologyBLASTP
3893139923993DNA replication protein DnaDQuickGO ontologyBLASTP
40078418081731hypothetical proteinBLASTP
4203042500471transcriptional regulator MarR familyQuickGO ontologyBLASTP
42506434809753-oxoacyl-acyl-carrier-protein synthase III Beta-ketoacyl-ACP synthase III KAS IIIQuickGO ontologyBLASTP
4351443744231acyl carrier proteinQuickGO ontologyBLASTP
4380444754951enoyl-acyl-carrier-protein reductase IIQuickGO ontologyBLASTP
4474745691945malonyl CoA-acyl carrier protein transacylaseQuickGO ontologyBLASTP
45691464437533-oxoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
464574769812423-oxoacyl-acyl-carrier-protein synthase IIQuickGO ontologyBLASTP
4770248190489acetyl-CoA carboxylase biotin carboxyl carrier proteinQuickGO ontologyBLASTP
4820348631429beta-hydroxyacyl-acyl-carrier-protein dehydratase FabZQuickGO ontologyBLASTP
48640499831344acetyl-CoA carboxylase biotin carboxylaseQuickGO ontologyBLASTP
5002950892864acetyl-CoA carboxylase carboxyl transferase beta subunitQuickGO ontologyBLASTP
5091651761846acetyl-CoA carboxylase carboxyl transferase alpha subunitQuickGO ontologyBLASTP
5194452786843amino acid ABC transporter substrate-binding proteinQuickGO ontologyBLASTP
5281853516699amino acid ABC transporter permease proteinQuickGO ontologyBLASTP
5350954231723ABC transporterQuickGO ontologyBLASTP
5445555078624hypothetical proteinBLASTP
55356577102355DNA repair helicase truncation putativeQuickGO ontologyBLASTP
57986591401155transposase Mutator familyQuickGO ontologyBLASTP
59367608061440ISBma2 transposaseQuickGO ontologyBLASTP