Pre_GI Gene

Some Help

Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:640000 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6401206412291110ethanolamine transporter ethanolamine utilizationQuickGO ontologyBLASTP
6412266430071782peptidase M24 family proteinQuickGO ontologyBLASTP
6436286454301803tetanolysin OQuickGO ontologyBLASTP
6454866466191134ATP-dependent RNA helicaseQuickGO ontologyBLASTP
6467586481881431ATP-dependent RNA helicaseQuickGO ontologyBLASTP
648290649051762transcription regulator IclR family BH2137QuickGO ontologyBLASTP
6492306498836542-dehydro-3-deoxyphosphogluconate aldolase4-hydroxy-2-oxoglutarate aldolase putativeQuickGO ontologyBLASTP
64989565091710232-dehydro-3-deoxygluconokinaseQuickGO ontologyBLASTP
651050651724675transcriptional regulator GntR family putativeQuickGO ontologyBLASTP
6519846537021719dihydroxyacid dehydrataseQuickGO ontologyBLASTP
6538316552011371gluconate permeaseQuickGO ontologyBLASTP
655331656056726glucosamine-6-phosphate isomeraseQuickGO ontologyBLASTP
656516656767252hypothetical proteinBLASTP
6567716578171047biotin synthaseQuickGO ontologyBLASTP
6578196591951377thiH proteinQuickGO ontologyBLASTP
6592126604021191GTP-binding proteinQuickGO ontologyBLASTP
660579660932354hypothetical proteinBLASTP
660941661798858ferredoxinQuickGO ontologyBLASTP
661786662643858MinD superfamily P-loop ATPase containing an inserted ferredoxin domainQuickGO ontologyBLASTP