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Query: NC_008593:1461771 Clostridium novyi NT, complete genome

Start: 1461771, End: 1484982, Length: 23212

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_014328:1307490*1307490133121623727Clostridium ljungdahlii ATCC 49587 chromosome, complete genome9e-105389BLASTN svgBLASTP svg
NC_003030:1811820*1811820183505323234Clostridium acetobutylicum ATCC 824, complete genome3e-98367BLASTN svgBLASTP svg
NC_021182:2422226*2422226244735325128Clostridium pasteurianum BC1, complete genome3e-86327BLASTN svgBLASTP svg
NC_003366:2057656*2057656208209924444Clostridium perfringens str. 13, complete genome4e-64254BLASTN svgBLASTP svg
NC_008262:1950205*1950205196967819474Clostridium perfringens SM101, complete genome2e-62248BLASTN svgBLASTP svg
NC_015687:1811573*1811573183463823066Clostridium acetobutylicum DSM 1731 chromosome, complete genome7e-44186BLASTN svgBLASTP svg
NC_006831:62290662290664732924424Ehrlichia ruminantium str. Gardel, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_006832:62705762705765166924613Ehrlichia ruminantium str. Welgevonden, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_005295:64727564727567182424550Ehrlichia ruminantium str. Welgevonden, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_014720:1161841*1161841118148419644Caldicellulosiruptor kronotskyensis 2002 chromosome, complete5e-1487.7BLASTN svgBLASTP svg
NC_004193:375416*375416683449308034Oceanobacillus iheyensis HTE831, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_003454:1346500*1346500136586219363Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete7e-1383.8BLASTN svgBLASTP svg
NC_014657:673500*67350069431420815Caldicellulosiruptor owensensis OL chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_002952:1291444*1291444131490923466Staphylococcus aureus subsp. aureus MRSA252, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_014377:1089894*1089894110909919206Thermosediminibacter oceani DSM 16646 chromosome, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_015949:1180755*1180755121693036176Caldicellulosiruptor lactoaceticus 6A chromosome, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_014721:1777644*1777644181600538362Caldicellulosiruptor kristjanssonii 177R1B chromosome, complete3e-0971.9BLASTN svgBLASTP svg
NC_014657:1193985*1193985121535121367Caldicellulosiruptor owensensis OL chromosome, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_014652:1032711*1032711107395141241Caldicellulosiruptor hydrothermalis 108 chromosome, complete3e-0971.9BLASTN svgBLASTP svg
NC_012034:1783912*1783912182367039759Anaerocellum thermophilum DSM 6725, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_009437:2367842*2367842241150043659Caldicellulosiruptor saccharolyticus DSM 8903, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_013517:2633574*2633574265613222559Sebaldella termitidis ATCC 33386, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_019978:2036779*2036779205929022512Halobacteroides halobius DSM 5150, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_016012:805680*80568082784122162Candidatus Arthromitus sp. SFB-rat-Yit, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_011772:4321117*4321117433922618110Bacillus cereus G9842, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_009782:1327340*1327340135080023461Staphylococcus aureus subsp. aureus Mu3, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_014150:1304573*1304573132443919867Brachyspira murdochii DSM 12563 chromosome, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_013515:347671*34767139636648696Streptobacillus moniliformis DSM 12112, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_010830:92326692326694501721752Candidatus Amoebophilus asiaticus 5a2, complete genome3e-0661.9BLASTN svgBLASTP svg