Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1060548 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10605481061324777membrane spanning proteinQuickGO ontologyBLASTP
106147810627131236serine hydroxymethyltransferaseQuickGO ontologyBLASTP
106322510667313507pyruvateferredoxin flavodoxin oxidoreductaseQuickGO ontologyBLASTP
10669101067272363hypothetical proteinBLASTP
10673421067983642HAD-superfamily subfamily IB hydrolase TIGR01490QuickGO ontologyBLASTP
10679961068817822branched-chain amino acid aminotransferase putativeQuickGO ontologyBLASTP
106891910708861968PTS enzyme II ABC componentQuickGO ontologyBLASTP
107108710730541968hypothetical proteinBLASTP
10730671073519453chemotaxis protein cheWQuickGO ontologyBLASTP
10735291074017489chemotaxis protein CheDQuickGO ontologyBLASTP
107403310750941062protein-glutamate methylesterase CheBQuickGO ontologyBLASTP
10750971075864768chemotaxis protein methyltransferase cheRQuickGO ontologyBLASTP
107587710779402064chemotaxis protein cheAQuickGO ontologyBLASTP
10779531078555603chemotaxis protein CheCQuickGO ontologyBLASTP
10785711078930360chemotaxis protein cheYQuickGO ontologyBLASTP
10789721079370399chemotaxis signal transduction protein CheWQuickGO ontologyBLASTP
10793911080386996flagellar motor switch protein FliMQuickGO ontologyBLASTP
108037910815691191flagellar switch protein FliY contains CheC-like domainQuickGO ontologyBLASTP
10817791082039261regulator of flagellin synthesis FLGMQuickGO ontologyBLASTP
10821441082542399hypothetical proteinBLASTP
108256410845942031flagellar hook-associated protein 1QuickGO ontologyBLASTP
10846251085602978flagellar hook-associated protein 3 putativeQuickGO ontologyBLASTP