Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:2281896 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
22818962282849954D-isomer specific 2-hydroxyacid dehydrogenasesQuickGO ontologyBLASTP
22830222283285264mannose-1-phosphate guanylyltransferase putativeQuickGO ontologyBLASTP
228345522846361182acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
228471122855568463-hydroxybutyryl-CoA dehydrogenase Beta-hydroxybutyryl-CoA dehydrogenase BHBDQuickGO ontologyBLASTP
228592222875051584glycerol kinaseQuickGO ontologyBLASTP
22875122288222711glycerol uptake facilitator proteinQuickGO ontologyBLASTP
228842322903271905methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
229040822919041497glycerol kinaseQuickGO ontologyBLASTP
22921232292839717glycerol uptake facilitator proteinQuickGO ontologyBLASTP
22931372293508372hypothetical proteinBLASTP
229351522947741260sarcosine oxidase alpha subunitQuickGO ontologyBLASTP
229482522962581434glycerol-3-phosphate dehydrogenaseQuickGO ontologyBLASTP
22964902297056567glycerol uptake operon antiterminator regulatory proteinQuickGO ontologyBLASTP
22973352297838504hypothetical proteinBLASTP
229810222993521251Xaa-Pro aminopeptidase putativeQuickGO ontologyBLASTP
22994942300201708Probable 2-phosphosulfolactate phosphataseQuickGO ontologyBLASTP
23002772300477201cold shock protein cspBQuickGO ontologyBLASTP
23010622301229168hypothetical proteinBLASTP
23013212301476156hypothetical proteinBLASTP
23019242302418495shikimate kinaseQuickGO ontologyBLASTP
23024332303245813shikimate 5-dehydrogenaseQuickGO ontologyBLASTP
23032572303529273chorismate mutaseQuickGO ontologyBLASTP
230354523046151071chorismate synthaseQuickGO ontologyBLASTP
2304593230590013083-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP