Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1103293 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
110329311053052013sulfatase-domain-containing proteinQuickGO ontologyBLASTP
11053181106262945licB protein putativeQuickGO ontologyBLASTP
11064411107247807flagellinQuickGO ontologyBLASTP
11072781108111834flagellinQuickGO ontologyBLASTP
11084341108838405flagellar basal-body rod protein FlgBQuickGO ontologyBLASTP
11088411109278438flagellar basal-body rod protein FlgCQuickGO ontologyBLASTP
11093411109652312flagellar hook-basal body complex protein FliEQuickGO ontologyBLASTP
110966811112391572flagellar M-ring protein FliFQuickGO ontologyBLASTP
111124511122581014flagellar motor switch protein FliGQuickGO ontologyBLASTP
11122421113039798putative fliH proteinQuickGO ontologyBLASTP
111307311143891317flagellum-specific ATP synthaseQuickGO ontologyBLASTP
11144101114844435flagellar protein fliJQuickGO ontologyBLASTP
111486511162171353putative flagellar hook-length control proteinQuickGO ontologyBLASTP
11162291117053825flagellar hook assembly protein FlgDQuickGO ontologyBLASTP
11170721117473402hypothetical proteinBLASTP
111754211189991458flagellar basal-body rod protein FlgGQuickGO ontologyBLASTP
11191601119351192flagellar protein flbD -related proteinQuickGO ontologyBLASTP
11193651120174810chemotaxis motA proteinQuickGO ontologyBLASTP
11201671120892726chemotaxis motB proteinQuickGO ontologyBLASTP
11208941121382489flagellar protein FliLQuickGO ontologyBLASTP
11213941121750357flagellar biosynthesis protein FliZQuickGO ontologyBLASTP
11217471122520774flagellar biosynthetic protein fliPQuickGO ontologyBLASTP
11225311122800270flagellar biosynthetic protein FliQQuickGO ontologyBLASTP
112291811246451728flagellar biosynthetic protein FlhBQuickGO ontologyBLASTP