Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:2527064 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
335469135ribosomal protein L34QuickGO ontologyBLASTP
527868342ribonuclease P protein componentQuickGO ontologyBLASTP
8681080213conserved hypothetical protein TIGR00278QuickGO ontologyBLASTP
10991839741Membrane protein oxaAQuickGO ontologyBLASTP
19032532630R3H domain proteinQuickGO ontologyBLASTP
259439731380tRNA modification GTPase TrmEQuickGO ontologyBLASTP
398658841899glucose-inhibited division protein AQuickGO ontologyBLASTP
58856616732glucose-inhibited division protein BQuickGO ontologyBLASTP
67097488780spoOJ protein putativeQuickGO ontologyBLASTP
76948479786Sporulation initiation inhibitor protein sojQuickGO ontologyBLASTP
252706425291842121sensor histidine kinaseQuickGO ontologyBLASTP
252942125321472727hypothetical proteinBLASTP
253216425326765133H domain proteinQuickGO ontologyBLASTP
25326902533199510hypothetical proteinBLASTP
2533304253337976tRNA-AlaQuickGO ontologyBLASTP
2533383253345977tRNA-MetQuickGO ontologyBLASTP
253346325335791175S ribosomal RNAQuickGO ontologyBLASTP
25336582536562290523S ribosomal RNAQuickGO ontologyBLASTP
25340382534679642hypothetical proteinBLASTP
25367512538243149316S ribosomal RNAQuickGO ontologyBLASTP
253863025411612532DNA gyrase A subunitQuickGO ontologyBLASTP
254118325430961914DNA gyrase B subunitQuickGO ontologyBLASTP
25431122543381270hypothetical proteinBLASTP
254340225444871086recF proteinQuickGO ontologyBLASTP
25445432544749207S4 domain proteinQuickGO ontologyBLASTP
254478625458891104DNA polymerase III beta subunitQuickGO ontologyBLASTP
254614725474931347chromosomal replication initiator protein DnaAQuickGO ontologyBLASTP