Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:609723 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6097236113841662probable ABC transporterQuickGO ontologyBLASTP
611561611848288PTS system IIB componentQuickGO ontologyBLASTP
6120356137591725DNAk proteinQuickGO ontologyBLASTP
6137826149331152conserved protein putativeQuickGO ontologyBLASTP
6149676163431377TPR domain proteinQuickGO ontologyBLASTP
616718617200483transcription regulator LrpAsnC family BH3351QuickGO ontologyBLASTP
6171976183691173aspartate aminotransferaseQuickGO ontologyBLASTP
6185476212672721Leucine Rich Repeat domain proteinQuickGO ontologyBLASTP
6213566263835028hypothetical proteinBLASTP
6264666279051440ISBma2 transposaseQuickGO ontologyBLASTP
628245629015771Transcriptional regulator of sugar metabolism putativeQuickGO ontologyBLASTP
6290536301741122pleiotropic regulatory proteinQuickGO ontologyBLASTP
6302866314791194spore coat polysaccharide biosynthesis protein spsCQuickGO ontologyBLASTP
6316616329111251hypothetical proteinBLASTP