Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:980731 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9807319824731743phosphomannomutaseQuickGO ontologyBLASTP
9826869837651080TPR repeats containing proteinQuickGO ontologyBLASTP
983804984718915UTP-glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
9848959867331839Polysaccharide biosynthesis protein superfamilyQuickGO ontologyBLASTP
9869129882281317UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
9882909894021113lipopolysaccharide biosynthesis proteinQuickGO ontologyBLASTP
989422990162741acyl-acyl-carrier-protein-UDP-N- acetylglucosamine acyltransferaseQuickGO ontologyBLASTP
990337991047711Acylneuraminate cytidylyltransferaseQuickGO ontologyBLASTP
9910409920981059Sialic acid synthaseQuickGO ontologyBLASTP
9921179932651149UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
993300993938639hexapeptide transferase family proteinQuickGO ontologyBLASTP
9939469949921047probable sugar-phosphate nucleotide transferaseQuickGO ontologyBLASTP
995017996012996UDP-glucose 4-epimeraseQuickGO ontologyBLASTP
9960279971241098perosamine synthetase putativeQuickGO ontologyBLASTP
9972499987961548integral membrane protein MviNQuickGO ontologyBLASTP
99881810001731356hypothetical protein
100020410013281125putative glycosyl transferaseQuickGO ontologyBLASTP
100133010024211092glycosyl transferase group 1 family protein putativeQuickGO ontologyBLASTP
100246910039531485hypothetical proteinBLASTP
100398210050071026succinoglycan biosynthesis protein exoAQuickGO ontologyBLASTP