Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1859861 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18598611860499639hypothetical proteinBLASTP
186063118616501020hypothetical proteinBLASTP
186164018634241785hypothetical proteinBLASTP
18634371864129693CRISPR-associated protein TM1814 familyQuickGO ontologyBLASTP
18664861866800315hypothetical proteinBLASTP
18668121867072261hypothetical proteinBLASTP
18707151871470756transglutaminase-like enzyme putative cysteine proteaseQuickGO ontologyBLASTP
18717051872298594sortase family proteinQuickGO ontologyBLASTP
187236818750462679putative S-layer protein peptidoglycan anchoredQuickGO ontologyBLASTP
187539818764531056conserved membrane protein putativeQuickGO ontologyBLASTP
18766501878707205823-cyclic-nucleotide 2-phosphodiesteraseQuickGO ontologyBLASTP
18788571879687831hypothetical proteinBLASTP
187971018809211212Hypothetical UPF0261 proteinQuickGO ontologyBLASTP
188111318822881176transcriptional regulator araC family proteinQuickGO ontologyBLASTP
18824891883487999hypothetical proteinBLASTP