Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1362218 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
136221813645752358hypothetical proteinBLASTP
136458813656761089ATPase AAA-like proteinQuickGO ontologyBLASTP
136591713672121296N-acetylmuramoyl-L-alanine amidase cwlL precursor Cellwall hydrolase AutolysinQuickGO ontologyBLASTP
13672511367511261ImmQuickGO ontologyBLASTP
136757513693861812Phage endopeptidaseQuickGO ontologyBLASTP
13694701369604135Gp17 protein-related proteinQuickGO ontologyBLASTP
13695971369932336hypothetical proteinBLASTP
136994313717871845phage pre-neck appendage-like proteinQuickGO ontologyBLASTP
13717781372461684conserved phage-related proteinQuickGO ontologyBLASTP
137246413750132550phage tail tape meausure protein TP901 family putativeQuickGO ontologyBLASTP
13750261375253228peptide methionine sulfoxide reductase domain protein putativeQuickGO ontologyBLASTP
13753191375696378hypothetical proteinBLASTP
13757131375970258hypothetical protein
13760201376649630hypothetical proteinBLASTP
13766511377019369hypothetical proteinBLASTP
13770241377422399hypothetical proteinBLASTP
13774151377744330phage head-tail adaptor putativeQuickGO ontologyBLASTP
13777441378298555hypothetical proteinBLASTP
13783441379036693hypothetical proteinBLASTP
13791971379793597scaffold proteinQuickGO ontologyBLASTP
13799111380420510hypothetical proteinBLASTP
13805121380736225hypothetical proteinBLASTP
138074113820121272minor head proteinQuickGO ontologyBLASTP
138199913834621464Phage portal protein SPP1 Gp6-likeQuickGO ontologyBLASTP