Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1513107 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
151310715148731767single-stranded-DNA-specific exonuclease RecJQuickGO ontologyBLASTP
15149531515771819endonuclease IVQuickGO ontologyBLASTP
15158081516413606flavin reductase domain protein putativeQuickGO ontologyBLASTP
15165081516720213copper ion binding proteinQuickGO ontologyBLASTP
151675915192062448copper-translocating P-type ATPaseQuickGO ontologyBLASTP
151934815205651218zinc proteaseQuickGO ontologyBLASTP
152072115217281008electron transfer flavoprotein alpha subunitQuickGO ontologyBLASTP
15217591522538780Electron transfer flavoprotein beta-subunit Beta-ETF Electrontransfer flavoprotein small subunit ETFSSQuickGO ontologyBLASTP
1522566152370511403-hydroxybutyryl-coA dehydrogenaseQuickGO ontologyBLASTP
152395515268672913DNA gyrase A subunitQuickGO ontologyBLASTP
152690715288651959DNA topoisomerase IV subunit BQuickGO ontologyBLASTP
15290601529443384hypothetical proteinBLASTP
15295181530456939conserved protein tetratricopeptide repeat family proteinQuickGO ontologyBLASTP
15305321531233702purine nucleoside phosphorylaseQuickGO ontologyBLASTP
153164015333731734methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
153366915350931425ISBma2 transposaseQuickGO ontologyBLASTP
15351921535404213hypothetical protein
153564915368241176cyclopropane fatty acid synthase family proteinQuickGO ontologyBLASTP