Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:2136759 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
213675921383241566ATP-dependent Clp protease ATPase subunit putativeQuickGO ontologyBLASTP
213832621394531128hypothetical protein
213982521413631539GMP synthaseQuickGO ontologyBLASTP
214157621430301455inosine-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
21434082144145738hypothetical proteinBLASTP
214421521458461632chaperonin GroELQuickGO ontologyBLASTP
21459512146235285chaperonin 10 kDaQuickGO ontologyBLASTP
214654821480321485Fe-hydrogenase large subunit family proteinQuickGO ontologyBLASTP
214821121490898798-oxoguanine-DNA-glycosylase putativeQuickGO ontologyBLASTP
214933221507201389glutamate synthase NADPH homotetramericQuickGO ontologyBLASTP
21507202151628909glutamate synthase small subunitQuickGO ontologyBLASTP
215182321529891167NADPH-dependent butanol dehydrogenaseQuickGO ontologyBLASTP
215323221551271896Signal-transduction and transcriptional-control proteinQuickGO ontologyBLASTP