Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1797000 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17970211797974954pyruvate synthase subunit porBQuickGO ontologyBLASTP
179798717991741188pyruvate synthase subunit porAQuickGO ontologyBLASTP
17991911799493303pyruvate synthase subunit porDQuickGO ontologyBLASTP
17994801800064585pyruvate synthase subunit porCQuickGO ontologyBLASTP
180015418015271374NaH antiporter family proteinQuickGO ontologyBLASTP
180175618029641209methionine gamma-lyaseQuickGO ontologyBLASTP
180334018049021563transcriptional regulatorQuickGO ontologyBLASTP
1805317180539175tRNA-AsnQuickGO ontologyBLASTP
18054481808352290523S ribosomal RNAQuickGO ontologyBLASTP
18058281806469642hypothetical proteinBLASTP
1808480180855677tRNA-IleQuickGO ontology
1808560180863576tRNA-AlaQuickGO ontologyBLASTP
18087781810270149316S ribosomal RNAQuickGO ontologyBLASTP
18106911811137447hypothetical proteinBLASTP
18112831812143861Putative undecaprenol kinase 2 Bacitracin resistanceprotein 2QuickGO ontologyBLASTP
181223418133821149hypothetical proteinBLASTP
18134581814336879cation efflux family protein putativeQuickGO ontologyBLASTP
18145021815500999Catabolite control protein AQuickGO ontologyBLASTP
18156041816518915ribose ABC transporter periplasmic D-ribose-binding proteinQuickGO ontologyBLASTP
18165401817475936ribose ABC transporter permease proteinQuickGO ontologyBLASTP
181750118190061506ribose transport ATP-binding protein rbsAQuickGO ontologyBLASTP
18190171819412396ribose ABC transporter protein RbsDQuickGO ontologyBLASTP
18194131820345933ribokinaseQuickGO ontologyBLASTP
18204691820753285hypothetical proteinBLASTP
182085618220131158Amidohydrolase family proteinQuickGO ontologyBLASTP