Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:555463 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5554635564671005glyceraldehyde-3-phosphate dehydrogenase type IQuickGO ontologyBLASTP
556670556789120hypothetical protein
5569795584181440ISBma2 transposaseQuickGO ontologyBLASTP
5586865598071122lipoproteinQuickGO ontologyBLASTP
5599225614871566sugar ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
5614955625711077Branched-chain amino acid transport system permease component superfamily putativeQuickGO ontologyBLASTP
562564563481918ABC transporter permease proteinQuickGO ontologyBLASTP
5637985649941197phosphoglycerate kinaseQuickGO ontologyBLASTP
565115565867753triosephosphate isomeraseQuickGO ontologyBLASTP
565940567475153623-bisphosphoglycerate-independent phosphoglycerate mutaseQuickGO ontologyBLASTP
5675895688901302enolaseQuickGO ontologyBLASTP
569082569312231preprotein translocase SecG subunitQuickGO ontologyBLASTP
5695285715462019V-type H-translocating pyrophosphataseQuickGO ontologyBLASTP
5717955740322238ribonuclease RQuickGO ontologyBLASTP
574164574637474SsrA-binding proteinQuickGO ontologyBLASTP
574730575072343sRNAQuickGO ontology
5764895778441356ATPase involved in DNA repair putativeQuickGO ontologyBLASTP
5778685793911524ATPase involved in DNA repair putativeQuickGO ontologyBLASTP