Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:2020473 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
202047320226592187DNA topoisomeraseQuickGO ontologyBLASTP
202270520243931689deoxyguanosinetriphosphate triphosphohydrolase putativeQuickGO ontologyBLASTP
202482320262591437prolyl-tRNA synthetaseQuickGO ontologyBLASTP
20263972026882486citrulline cluster-linked geneQuickGO ontologyBLASTP
20272002027766567putative rRNA methylaseQuickGO ontologyBLASTP
202788120279971175S ribosomal RNAQuickGO ontologyBLASTP
20280342030938290523S ribosomal RNAQuickGO ontologyBLASTP
20284142029055642hypothetical proteinBLASTP
20311272032619149316S ribosomal RNAQuickGO ontologyBLASTP
20330862034165108023-butanediol dehydrogenaseQuickGO ontologyBLASTP
203436020363391980aco operon expression regulatory proteinQuickGO ontologyBLASTP
2036464203653774tRNA-GlyQuickGO ontologyBLASTP
2036553203662977tRNA-IleQuickGO ontology
2036634203670976tRNA-AlaQuickGO ontologyBLASTP
20369932037544552Appr-1-p processing enzyme family proteinQuickGO ontologyBLASTP
20378422038495654lytic murein transglycosylase putativeQuickGO ontologyBLASTP
20386062039430825hypothetical proteinBLASTP
20394572040431975hypothetical proteinBLASTP
20405712040738168hypothetical proteinBLASTP
204089220422081317Metallo-beta-lactamase superfamily proteinQuickGO ontologyBLASTP
20422392042979741short chain dehydrogenasereductase family proteinQuickGO ontologyBLASTP
20430092043530522cobIalamin adenosyltransferaseQuickGO ontologyBLASTP