Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:153014 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1530141554102397stage II sporulation protein EQuickGO ontologyBLASTP
1555461569401395Cell cycle protein MesJ putativeQuickGO ontologyBLASTP
156942157481540hypoxanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
1575521595822031ATP-dependent metalloprotease FtsHQuickGO ontologyBLASTP
159725160111387hypothetical proteinBLASTP
1602131618831671formate--tetrahydrofolate ligaseQuickGO ontologyBLASTP
162007162786780transcriptional activator putative Baf family proteinQuickGO ontologyBLASTP
162795163760966nifR3 family enzymeQuickGO ontologyBLASTP
163989164468480transcription elongation factor greAQuickGO ontologyBLASTP
1645181660501533lysyl-tRNA synthetaseQuickGO ontologyBLASTP
16617816625275tRNA-AsnQuickGO ontology
1665351679261392glycyl-tRNA synthetaseQuickGO ontologyBLASTP
1682921696681377UDP-N-acetylmuramoylalanine--D-glutamate ligaseQuickGO ontologyBLASTP
170261171753149316S ribosomal RNAQuickGO ontologyBLASTP