Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:1461771 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14617711462397627uridine kinaseQuickGO ontologyBLASTP
146240114636271227peptidase U32 familyQuickGO ontologyBLASTP
14636201464276657O-methyltransferase family putativeQuickGO ontologyBLASTP
146430714653171011hypothetical proteinBLASTP
146535914671791821GTP-binding protein TypAQuickGO ontologyBLASTP
14673211467665345Protein of unknown function DUF964 superfamilyQuickGO ontologyBLASTP
146769014693571668predicted hydrolase of the metallo-beta-lactamase superfamilyQuickGO ontologyBLASTP
14693961469848453ferric uptake regulation proteinQuickGO ontologyBLASTP
14700021470262261hypothetical proteinBLASTP
14702861470693408Putative Holliday junction resolvaseQuickGO ontologyBLASTP
14707511471005255Hypothetical UPF0297 proteinQuickGO ontologyBLASTP
147109214737312640alanyl-tRNA synthetaseQuickGO ontologyBLASTP
147414514751971053tRNA 5-methylaminomethyl-2-thiouridylate-methyltransferaseQuickGO ontologyBLASTP
14752101475638429nifU proteinQuickGO ontologyBLASTP
147564114768311191cysteine desulfuraseQuickGO ontologyBLASTP
14768241477258435iron-sulfur cluster assembly transcription factor IscRQuickGO ontologyBLASTP
147734114786001260ATPase AAA familyQuickGO ontologyBLASTP
147874114799731233EAL domain protein putativeQuickGO ontologyBLASTP
14800771480739663Zn-dependent hydrolase glyoxylase II familyQuickGO ontologyBLASTP
148075814826651908ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
148272714849822256DNA topoisomerase IIIQuickGO ontologyBLASTP