Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:2250871 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
225087122518811011spore coat proteinQuickGO ontologyBLASTP
225200922531301122mannosyltransferase putativeQuickGO ontologyBLASTP
22531822254108927cysteine synthase AQuickGO ontologyBLASTP
22542792255070792anaerobic cobalt chelataseQuickGO ontologyBLASTP
22550542255833780precorrin-6x reductaseQuickGO ontologyBLASTP
22558302256576747precorrin-3B C17-methyltransferaseQuickGO ontologyBLASTP
225662622576601035cobalamin biosynthesis protein cbiGQuickGO ontologyBLASTP
22576692258406738precorrin-4 C11-methyltransferaseQuickGO ontologyBLASTP
22584172259082666precorrin-2 C20-methyltransferaseQuickGO ontologyBLASTP
22590842259662579precorrin-6B methylasedecarboxylase cbiTcbiEQuickGO ontologyBLASTP
22596592260279621precorrin-6B methylasedecarboxylase cbiTcbiEQuickGO ontologyBLASTP
226029822613741077cobalamin biosynthesis protein CbiDQuickGO ontologyBLASTP
22613962262019624precorrin-8X methylmutaseQuickGO ontologyBLASTP
226201222633671356cobyrinic acid ac-diamide synthaseQuickGO ontologyBLASTP
22637132264684972spore coat protein S putativeQuickGO ontologyBLASTP
22647252265537813spore coat proteinputativeQuickGO ontologyBLASTP
226556922665821014spore coat protein S putativeQuickGO ontologyBLASTP
226673222678441113mannosyltransferase putativeQuickGO ontologyBLASTP
226788822689341047methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP