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Query: NC_008261:3014373:3014373 Clostridium perfringens ATCC 13124, complete genome

Start: 3014373, End: 3014909, Length: 537

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2788268:279173427917342792333600Clostridium perfringens str. 13, complete genomehypothetical protein7e-93338
NC_008262:2649289:265792426579242658451528Clostridium perfringens SM101, complete genomehypothetical protein3e-90330
NC_015687:3326461:333256033325603333087528Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein2e-2098.6
NC_003030:3324834:333093333309333331460528Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized conserved protein, containing ClpE-like Zn-zinger domain; YACH B.subtilis ortholog2e-2098.6
NC_008593:196257:203395203395203919525Clostridium novyi NT, complete genomehypothetical protein1e-1995.5
NC_012563:4004709:400967240096724010199528Clostridium botulinum A2 str. Kyoto, complete genomeUVR domain protein6e-1890.1
NC_009706:165913:181847181847182395549Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-1787.8
NC_011837:165913:181829181829182395567Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-1787.4
NC_021182:4602683:460887346088734609397525Clostridium pasteurianum BC1, complete genomehypothetical protein6e-1787
NC_012658:3827500:383246938324693832996528Clostridium botulinum Ba4 str. 657 chromosome, complete genomeUVR domain-containing protein9e-1786.3
NC_015425:198315:208071208071208586516Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein9e-1786.3
NC_007644:161222:160716160716161225510Moorella thermoacetica ATCC 39073, complete genomeUvrB/UvrC protein1e-1685.9
NC_010520:3837378:384234238423423842869528Clostridium botulinum A3 str. Loch Maree, complete genomeUVR domain protein3e-1684.7
NC_010516:3807780:381274438127443813271528Clostridium botulinum B1 str. Okra, complete genomeUVR domain protein3e-1684.3
NC_009495:3735703:374174637417463742273528Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeUVR domain protein3e-1684.3
NC_009697:3711692:371773537177353718262528Clostridium botulinum A str. ATCC 19397 chromosome, completeUVR domain-containing protein3e-1684.3
NC_009698:3609881:361484436148443615371528Clostridium botulinum A str. Hall chromosome, complete genomeUVR domain-containing protein3e-1684.3
NC_009699:3839575:384453938445393845066528Clostridium botulinum F str. Langeland chromosome, complete genomeUVR domain-containing protein3e-1684.3
NC_017297:3838189:384315338431533843680528Clostridium botulinum F str. 230613 chromosome, complete genomeUVR domain protein3e-1684.3
NC_014328:4471995:447696144769614477509549Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative UvrB/UvrC domain-containing protein1e-1582.8
NC_007503:2098980:210718721071872107705519Carboxydothermus hydrogenoformans Z-2901, complete genomeuvrB/uvrC motif domain protein2e-1581.6
NC_016884:256598:274479274479275024546Sulfobacillus acidophilus DSM 10332 chromosome, complete genomeUvrB/UvrC protein4e-1580.9
NC_015757:263938:281819281819282364546Sulfobacillus acidophilus TPY chromosome, complete genomeUvrB/UvrC protein4e-1580.9
NC_013316:1:411774117741671495Clostridium difficile R20291, complete genomeputative DNA repair protein6e-1580.5
NC_019970:336472:347392347392347919528Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeuncharacterized protein with conserved CXXC pairs7e-1580.1
NC_009012:2100000:211492921149292115435507Clostridium thermocellum ATCC 27405, complete genomeUvrB/UvrC protein7e-1580.1
NC_011899:86800:102658102658103170513Halothermothrix orenii H 168, complete genomeUvrB/UvrC protein3e-1477.8
NC_015913:1491393:152834615283461528879534Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehypothetical protein8e-1476.6
NC_004557:2777291:278316727831672783685519Clostridium tetani E88, complete genomeputative clpC ATPase1e-1376.3
NC_002570:126500:133288133288133821534Bacillus halodurans C-125, complete genomehypothetical protein2e-1375.1
NC_010674:192951:214143214143214718576Clostridium botulinum B str. Eklund 17B, complete genomeMcsA2e-1375.1
NC_019903:421000:426780426780427277498Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein3e-1374.7
NC_010723:173280:215938215938216513576Clostridium botulinum E3 str. Alaska E43, complete genomeMcsA1e-1272.8
NC_020134:301500:304712304712305212501Clostridium stercorarium subsp. stercorarium DSM 8532, completeputative UvrB/UvrC protein1e-1272.4
NC_004193:79588:109929109929110486558Oceanobacillus iheyensis HTE831, complete genomehypothetical protein4e-1270.9
NC_011567:75306:894038940389954552Anoxybacillus flavithermus WK1, complete genomeModulator of heat shock repressor CtsR, McsA2e-1168.6
NC_014152:241776:260878260878261405528Thermincola sp. JR, complete genomeUvrB/UvrC protein1e-1065.9
NC_014378:131810:144738144738145265528Acetohalobium arabaticum DSM 5501 chromosome, complete genomeUvrB/UvrC protein3e-1064.7
NC_018704:81733:107554107554108102549Amphibacillus xylanus NBRC 15112, complete genomeputative activator protein McsA3e-0961.6
NC_014219:83888:102994102994103533540Bacillus selenitireducens MLS10 chromosome, complete genomeUvrB/UvrC protein5e-0960.5
NC_010001:4250828:426290642629064263427522Clostridium phytofermentans ISDg, complete genomeUvrB/UvrC protein6e-0960.5
NC_014654:2138794:214491221449122145457546Halanaerobium sp. 'sapolanicus' chromosome, complete genomeUvrB/UvrC protein1e-0859.3
NC_010382:4479464:449656944965694497117549Lysinibacillus sphaericus C3-41, complete genomehypothetical protein1e-0755.8
NC_017208:64500:969779697797525549Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeClpC ATPase2e-0755.5
NC_012778:688621:690234690234690833600Eubacterium eligens ATCC 27750, complete genomehypothetical protein2e-0755.1
NC_012489:1874415:189729318972931897778486Gemmatimonas aurantiaca T-27, complete genomehypothetical protein1e-0652.8