Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:4004709 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
400470940060671359DNA repair protein RadAQuickGO ontologyBLASTP
400618740086222436negative regulator of genetic competence MecBClpCQuickGO ontologyBLASTP
400862440096671044ATPguanido phosphotransferase domain proteinQuickGO ontologyBLASTP
40096724010199528UVR domain proteinQuickGO ontologyBLASTP
40102224010686465transciptional repressor CtsRQuickGO ontologyBLASTP
40110824011312231hypothetical proteinBLASTP
401165940137312073translation elongation factor GQuickGO ontologyBLASTP
4013917401399377tRNA-AsnQuickGO ontologyBLASTP
4014019401409577tRNA-AsnQuickGO ontologyBLASTP
401410340142191175S ribosomal RNAQuickGO ontologyBLASTP
40146904015346657hypothetical proteinBLASTP
40154204015875456hypothetical proteinBLASTP
4017285401736177tRNA-IleQuickGO ontology
40174484018949150216S ribosomal RNAQuickGO ontologyBLASTP
4019175401925278tRNA-AlaQuickGO ontologyBLASTP
4019254401933279tRNA-MetQuickGO ontologyBLASTP
401933940194551175S ribosomal RNAQuickGO ontologyBLASTP
40199294020585657hypothetical proteinBLASTP
40206594021114456hypothetical proteinBLASTP
40226724024173150216S ribosomal RNAQuickGO ontologyBLASTP
402474440261201377UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligaseQuickGO ontologyBLASTP
402694640283371392glycine--tRNA ligaseQuickGO ontologyBLASTP
402865740301711515lysine--tRNA ligaseQuickGO ontologyBLASTP
40301904030672483transcription elongation factor GreAQuickGO ontologyBLASTP
40308034031630828hypothetical proteinBLASTP
40316804032651972dihydrouridine synthaseQuickGO ontologyBLASTP
40326614033437777pantothenate kinase type IIIQuickGO ontologyBLASTP
403359240352651674formate--tetrahydrofolate ligaseQuickGO ontologyBLASTP
403546840372731806ATP-dependent metalloprotease FtsHQuickGO ontologyBLASTP