Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:3827500 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
382750538288631359DNA repair protein RadAQuickGO ontologyBLASTP
382898438314192436negative regulator of genetic competence MecBClpCQuickGO ontologyBLASTP
383142138324641044ATPguanido phosphotransferaseQuickGO ontologyBLASTP
38324693832996528UVR domain-containing proteinQuickGO ontologyBLASTP
38330193833483465transciptional repressor CtsRQuickGO ontologyBLASTP
38338793834109231hypothetical proteinBLASTP
383441338364852073elongation factor GQuickGO ontologyBLASTP
383685838369741175S ribosomal RNAQuickGO ontologyBLASTP
3841929384200678tRNA-AlaQuickGO ontologyBLASTP
384209338422091175S ribosomal RNAQuickGO ontologyBLASTP
384749838488741377UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP
384971938511101392glycyl-tRNA synthetaseQuickGO ontologyBLASTP