Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2777291 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
123042304negative regulator of genetic competence mecBQuickGO ontologyBLASTP
248739231437putative cardiolipin synthetase 2QuickGO ontologyBLASTP
40274548522DNA polymerase bacteriophage-typeQuickGO ontologyBLASTP
45845144561hypothetical proteinBLASTP
277729127786881398DNA repair protein radAQuickGO ontologyBLASTP
27787882779513726glucosamine-6-phosphate deaminaseQuickGO ontologyBLASTP
277966927821042436negative regulator of genetic competence mecBclpCQuickGO ontologyBLASTP
278213327831551023putative ATPguanido phosphotransferaseQuickGO ontologyBLASTP
27831672783685519putative clpC ATPaseQuickGO ontologyBLASTP
27837422784200459transcriptional regulator ctsRQuickGO ontologyBLASTP
27844242785065642phosphoglycerate mutaseQuickGO ontologyBLASTP
27855272786114588rubrerythrinQuickGO ontologyBLASTP
278617127882612091translation elongation factor EF-GQuickGO ontologyBLASTP
2788446278852075tRNA-AsnQuickGO ontology
27885402788627885S ribosomal RNAQuickGO ontologyBLASTP
27887892791633284523S ribosomal RNAQuickGO ontologyBLASTP
2791838279191477tRNA-IleQuickGO ontology
27919822793490150916S ribosomal RNAQuickGO ontologyBLASTP
2793666279374176tRNA-AlaQuickGO ontologyBLASTP
2793748279382477tRNA-MetQuickGO ontologyBLASTP
27938402793927885S ribosomal RNAQuickGO ontologyBLASTP
27941062796950284523S ribosomal RNAQuickGO ontologyBLASTP
2797155279723177tRNA-IleQuickGO ontology
27972992798807150916S ribosomal RNAQuickGO ontologyBLASTP