Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:3837378 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
383737838387361359DNA repair protein radAQuickGO ontologyBLASTP
383885738412922436negative regulator of genetic competence MecBClpCQuickGO ontologyBLASTP
384129438423371044ATPguanido phosphotransferase domain proteinQuickGO ontologyBLASTP
38423423842869528UVR domain proteinQuickGO ontologyBLASTP
38428923843356465transciptional repressor CtsRQuickGO ontologyBLASTP
38437523843982231hypothetical proteinBLASTP
384432838464002073translation elongation factor GQuickGO ontologyBLASTP
3846586384666277tRNA-AsnQuickGO ontologyBLASTP
3846688384676477tRNA-AsnQuickGO ontologyBLASTP
384677238468881175S ribosomal RNAQuickGO ontologyBLASTP
38469793849880290223S ribosomal RNAQuickGO ontologyBLASTP
3849954385003077tRNA-IleQuickGO ontology
38501173851618150216S ribosomal RNAQuickGO ontologyBLASTP
3851835385191278tRNA-AlaQuickGO ontologyBLASTP
3851914385199279tRNA-MetQuickGO ontologyBLASTP
385199938521151175S ribosomal RNAQuickGO ontologyBLASTP
38522083855109290223S ribosomal RNAQuickGO ontologyBLASTP
38553313856832150216S ribosomal RNAQuickGO ontologyBLASTP
385740438587801377UDP-N-acetylmuramoylalanine--D-glutamate ligaseQuickGO ontologyBLASTP