Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:192951 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1929511944561506lysyl-tRNA synthetaseQuickGO ontologyBLASTP
19469919477577tRNA-AsnQuickGO ontologyBLASTP
19509219516877tRNA-AsnQuickGO ontologyBLASTP
19547219554877tRNA-AsnQuickGO ontologyBLASTP
1959821973731392glycyl-tRNA synthetaseQuickGO ontologyBLASTP
1975601989361377UDP-N-acetylmuramoylalanine--D-glutamate ligaseQuickGO ontologyBLASTP
1990692000731005putative basic proteinQuickGO ontologyBLASTP
200072200206135hypothetical protein
200570202074150516S ribosomal RNAQuickGO ontologyBLASTP
20219920227678tRNA-AlaQuickGO ontologyBLASTP
20227920235577tRNA-IleQuickGO ontology
202464205374291123S ribosomal RNAQuickGO ontologyBLASTP
2054332055491175S ribosomal RNAQuickGO ontologyBLASTP
20555520563278tRNA-PheQuickGO ontology
20563320570674tRNA-CysQuickGO ontologyBLASTP
205989206936948magnesium and cobalt transporterQuickGO ontologyBLASTP
207213207689477hypothetical proteinBLASTP
2077502089101161amidohydrolaseQuickGO ontologyBLASTP
209071209241171putative CsfB proteinQuickGO ontologyBLASTP
209394210071678thymidylate kinaseQuickGO ontologyBLASTP
210186210518333protein from nitrogen regulatory protein P-IIQuickGO ontologyBLASTP
210530211462933DNA polymerase III subunits gamma and tauQuickGO ontologyBLASTP
211466212374909PSP1 domain proteinQuickGO ontologyBLASTP
212518212688171hypothetical proteinBLASTP
212846213484639hypothetical proteinBLASTP
213673214128456transcriptional regulator CtsRQuickGO ontologyBLASTP
214143214718576McsAQuickGO ontologyBLASTP
2147022157211020putative ATPguanido phosphotransferaseQuickGO ontologyBLASTP
2157462181902445negative regulator of genetic competence ClpCmecBQuickGO ontologyBLASTP
218482219417936putative thioredoxin reductaseQuickGO ontologyBLASTP