Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:3838189 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
383818938395471359DNA repair protein RadAQuickGO ontologyBLASTP
383966838421032436negative regulator of genetic competence MecBClpCQuickGO ontologyBLASTP
384210538431481044ATPguanido phosphotransferase domain proteinQuickGO ontologyBLASTP
38431533843680528UVR domain proteinQuickGO ontologyBLASTP
38437033844167465transciptional repressor CtsRQuickGO ontologyBLASTP
38445633844793231hypothetical proteinBLASTP
384515538472122058translation elongation factor GQuickGO ontologyBLASTP
3852661385273777tRNA-AlaQuickGO ontologyBLASTP
38597523859955204hypothetical proteinBLASTP
386043138618221392glycine--tRNA ligaseQuickGO ontologyBLASTP
386214238636561515lysine--tRNA ligaseQuickGO ontologyBLASTP
38636753864157483transcription elongation factor GreAQuickGO ontologyBLASTP
38642883865115828hypothetical proteinBLASTP
38651653866136972dihydrouridine synthaseQuickGO ontologyBLASTP
38661463866922777transcriptional activator Baf family proteinQuickGO ontologyBLASTP
386707738687501674formate--tetrahydrofolate ligaseQuickGO ontologyBLASTP
386895338707581806ATP-dependent metalloprotease FtsHQuickGO ontologyBLASTP