Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:2788268 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
278826827907122445ClpC adenosine triphosphataseQuickGO ontologyBLASTP
279073727917501014putative ATPguanido phosphotransferaseQuickGO ontologyBLASTP
27917342792333600hypothetical proteinBLASTP
27922812792736456transcriptional repressor of class III stress genesQuickGO ontologyBLASTP
27929532793606654hypothetical proteinBLASTP
279365727953181662hypothetical proteinBLASTP
27954562795626171ferredoxinQuickGO ontologyBLASTP
27957952796700906signal peptidase-like proteinQuickGO ontologyBLASTP
27967032797626924DNA polymerase III subunits gamma and tauQuickGO ontologyBLASTP
27976482797977330hypothetical proteinBLASTP
27981342798289156hypothetical proteinBLASTP
27983062798896591probable guanylate kinaseQuickGO ontologyBLASTP
279914328005731431probable lysine decarboxylaseQuickGO ontologyBLASTP
28005912800767177probable sigma-F transcribed proteinQuickGO ontologyBLASTP
280092328020921170hypothetical proteinBLASTP
28021212802618498hypothetical proteinBLASTP
28028932803837945probable transport proteinQuickGO ontologyBLASTP
28039022804810909hypothetical proteinBLASTP