Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_004741: Shigella flexneri 2a str. 2457T, complete genome

NCBI: NC_004741

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1310382*33778027399Island text2.4331936.355519.869Neighbours41BLASTN+IslandViewer 310382.gbk
236682238968922868Island text1.9458932.177226.1946Neighbours41BLASTNIslandViewer 366822.gbk
31792442181107618635Island text1.7091427.118819.034Neighbours41BLASTN+IslandViewer 1792442.gbk
41823000184104318044Island text1.745427.550519.8806Neighbours41BLASTN1823000.gbk
52009769203209922331Island text1.678732.587520.91Neighbours41BLASTN+IslandViewer 2009769.gbk
62081649211300631358Island text3.6741540.98924.7609Neighbours41BLASTNIslandViewer 2081649.gbk
72169877*219012220246Island text1.5941330.018829.0306Neighbours41BLASTN2169877.gbk
82456297247959923303Island text2.2072431.342120.7734Neighbours41BLASTNIslandViewer 2456297.gbk
92526421254776721347Island text1.8225530.063627.8475Neighbours41BLASTNIslandViewer 2526421.gbk
102593012261557622565Island text1.5933230.222516.5002Neighbours11BLASTN+IslandViewer 2593012.gbk
112741971*276422322253Island text1.4515532.131634.4804Neighbours41BLASTN+IslandViewer 2741971.gbk
123041294*310468963396Island text1.4861433.687830.7964Neighbours41BLASTN+IslandViewer PAI DB3041294.gbk
133240909*326236621458Island text1.9110430.955132.8333Neighbours41BLASTN+3240909.gbk
143992384*401736124978Island text2.5458634.683919.734Neighbours41BLASTNIslandViewer 3992384.gbk
154132056415578223727Island text2.6293133.572516.301Neighbours41BLASTNIslandViewer 4132056.gbk
164160500418981229313Island text2.7741836.878524.0285Neighbours41BLASTN+IslandViewer PAI DB4160500.gbk
174364235*438964325409Island text1.9975932.452925.1961Neighbours41BLASTN+IslandViewer PAI DB4364235.gbk