Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:2009769 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20097692010581813ISEhe3 orfBQuickGO ontologyBLASTP
20106382010916279ISEhe3 orfAQuickGO ontologyBLASTP
20109432011830888putative outer membrane pore proteinQuickGO ontologyBLASTP
20117552012639885insertion sequence 2 OrfB proteinQuickGO ontologyBLASTP
20126182013028411insertion sequence 2 OrfA proteinQuickGO ontologyBLASTP
20130472013256210putative outer membrane proteinQuickGO ontologyBLASTP
20138842014159276IS1 orfAQuickGO ontologyBLASTP
20140782014581504IS1 orfBQuickGO ontologyBLASTP
20146272015499873chaperone protein HchAQuickGO ontologyBLASTP
201558520169431359putative 2-component sensor proteinQuickGO ontologyBLASTP
20169432017614672putative 2-component transcriptional regulatorQuickGO ontologyBLASTP
20177472018160414hypothetical proteinBLASTP
20192742019909636hypothetical proteinBLASTP
20201672020817651hypothetical proteinBLASTP
20218952022164270putative bacteriophage proteinQuickGO ontologyBLASTP
202320520248481644invasion plasmid antigenQuickGO ontologyBLASTP
20250282025405378hypothetical bacteriophage proteinQuickGO ontologyBLASTP
20264622026737276IS1 orfAQuickGO ontologyBLASTP
20266562027159504IS1 orfBQuickGO ontologyBLASTP
202780220297511950putative tail proteinQuickGO ontologyBLASTP
20298362030171336hypothetical bacteriophage proteinQuickGO ontologyBLASTP
20301712030527357hypothetical bacteriophage proteinQuickGO ontologyBLASTP
203052720320231497putative sheath proteinQuickGO ontologyBLASTP