Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:3992384 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39923843993052669DNA repair protein RadCQuickGO ontologyBLASTP
3993269399350523750S ribosomal protein L28QuickGO ontologyBLASTP
3993526399369316850S ribosomal protein L33QuickGO ontologyBLASTP
39937913994600810formamidopyrimidine-DNA glycosylaseQuickGO ontologyBLASTP
39946393995118480phosphopantetheine adenylyltransferaseQuickGO ontologyBLASTP
3995126399640312783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
39965373996812276IS1 orfAQuickGO ontologyBLASTP
39967313997234504IS1 orfBQuickGO ontologyBLASTP
399759239986501059lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
399864739997711125LPS alpha13-glucosyltransferaseQuickGO ontologyBLASTP
39997554000561807lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
400060440016111008UDP-D-galactoseglucosyllipopolysaccharide- alpha-13-D-galactosyltransferaseQuickGO ontologyBLASTP
40016374002344708putative LPS biosynthesis proteinQuickGO ontologyBLASTP
400236940033821014putative UDP-glucosegalactosyl LPS alpha12-glucosyltransferaseQuickGO ontologyBLASTP
400339140045331143lipopolysaccharide 12-N- acetylglucosaminetransferaseQuickGO ontologyBLASTP
400456940057771209lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
40057744006736963heptosyl transferase IQuickGO ontologyBLASTP
400677040078161047ADP-heptose--lps heptosyltransferase IIQuickGO ontologyBLASTP
40078264008758933ADP-L-glycero-D-mannoheptose-6-epimeraseQuickGO ontologyBLASTP
4010194401139011972-amino-3-ketobutyrate coenzyme A ligaseQuickGO ontologyBLASTP
401140040124251026L-threonine 3-dehydrogenaseQuickGO ontologyBLASTP
40126554012930276IS1 orfAQuickGO ontologyBLASTP
40128494013352504IS1 orfBQuickGO ontologyBLASTP
40134344013574141putative regulatorQuickGO ontologyBLASTP
40135614014394834hypothetical proteinBLASTP
401452440157831260hypothetical proteinBLASTP
401581740173611545phosphoglyceromutaseQuickGO ontologyBLASTP