Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:2526421 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25264212527290870N-acetylmuramoyl-l-alanine amidase IQuickGO ontologyBLASTP
25282002528760561putative ARAC-type regulatory proteinQuickGO ontologyBLASTP
25292982529798501hypothetical proteinBLASTP
25298112530470660hypothetical proteinBLASTP
25318232532224402hypothetical proteinBLASTP
25331622533557396hypothetical proteinBLASTP
25335752533838264hypothetical proteinBLASTP
25338612534403543hypothetical proteinBLASTP
25345002534829330hypothetical proteinBLASTP
25348682535074207hypothetical proteinBLASTP
25356592535871213hypothetical proteinBLASTP
253612325375831461putative amino acid antiporterQuickGO ontologyBLASTP
25385452538940396IS1N orfBQuickGO ontologyBLASTP
25389672539239273IS1N orfAQuickGO ontologyBLASTP
25411062541585480hypothetical proteinBLASTP
25415982542005408hypothetical proteinBLASTP
254222625445052280phosphate acetyltransferaseQuickGO ontologyBLASTP
25447942545744951transaldolaseQuickGO ontologyBLASTP
254576425477672004transketolaseQuickGO ontologyBLASTP