Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:2456297 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24562972456599303IS911 orfAQuickGO ontologyBLASTP
24565802457185606IS4 orfQuickGO ontologyBLASTP
245750124589341434hypothetical proteinBLASTP
245894224600001059sucrose specific repressorQuickGO ontologyBLASTP
246040424617321329D-serine dehydrataseQuickGO ontologyBLASTP
246184024633781539multidrug resistance protein YQuickGO ontologyBLASTP
246337824645411164multidrug resistance protein KQuickGO ontologyBLASTP
24649572465571615putative positive transcription regulator sensor EvgSQuickGO ontologyBLASTP
246557624691693594putative sensor for regulator EvgAQuickGO ontologyBLASTP
246922524703701146putative enzymeQuickGO ontologyBLASTP
247145724731511695hypothetical proteinBLASTP
247320524744551251formyl-coenzyme A transferaseQuickGO ontologyBLASTP
24749682475591624hypothetical proteinBLASTP
24758882476163276hypothetical proteinBLASTP
24762402476482243hypothetical proteinBLASTP
24767692477755987lipid A biosynthesis lauroyl acyltransferaseQuickGO ontologyBLASTP
247824624794841239hypothetical proteinBLASTP