Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:3041294 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
304129430434892196ornithine decarboxylase isozymeQuickGO ontologyBLASTP
30438273044534708putative transport proteinQuickGO ontologyBLASTP
3044640304471576tRNA-PheQuickGO ontologyBLASTP
304491330461751263putative P4-type integraseQuickGO ontologyBLASTP
304662830501433516putative superfamily I DNA helicaseQuickGO ontologyBLASTP
30514923052253762hypothetical proteinBLASTP
305261430564713858serine proteaseQuickGO ontologyBLASTP
30595453059763219hypothetical proteinBLASTP
305991430631263213serine protease precurserQuickGO ontologyBLASTP
30647603065593834reverse transcriptase-like proteinQuickGO ontologyBLASTP
30655873066267681reverse transcriptase-like proteinQuickGO ontologyBLASTP
30673533067679327IS629 orfAQuickGO ontologyBLASTP
30679623068387426hypothetical proteinBLASTP
30683843068767384hypothetical proteinBLASTP
30691403069739600hypothetical proteinBLASTP
30704113070821411insertion sequence 2 OrfA proteinQuickGO ontologyBLASTP
30708003071684885insertion sequence 2 OrfB proteinQuickGO ontologyBLASTP
30735383073744207hypothetical proteinBLASTP
30738303074402573hypothetical proteinBLASTP
30744043074688285hypothetical proteinBLASTP
307597130769901020hypothetical proteinBLASTP
30771003077972873hypothetical proteinBLASTP
30783063079199894outer membrane fluffing proteinQuickGO ontologyBLASTP
307930530814252121outer membrane fluffing proteinQuickGO ontologyBLASTP
308154630840622517hypothetical proteinBLASTP
30841383084593456hypothetical proteinBLASTP
30850043085822819hypothetical proteinBLASTP
30861643086637474hypothetical proteinBLASTP
30866383087129492putative RADC family DNA repair proteinQuickGO ontologyBLASTP
30872163087437222hypothetical proteinBLASTP
30875173087894378putative structural proteinQuickGO ontologyBLASTP
30879413088318378hypothetical proteinBLASTP
30883153088803489hypothetical proteinBLASTP
30891053089947843hypothetical proteinBLASTP
30913723091671300IS3 orfAQuickGO ontologyBLASTP
30916683092534867IS3 orfBQuickGO ontologyBLASTP
30931713093410240hypothetical proteinBLASTP
30935453094150606hypothetical proteinBLASTP
30942653094768504IS1 orfBQuickGO ontologyBLASTP
30946873094962276IS1 orfAQuickGO ontologyBLASTP
309636530979511587putative permeaseQuickGO ontologyBLASTP
309830631004772172malate synthaseQuickGO ontologyBLASTP
31004993100903405hypothetical proteinBLASTP