Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:2593012 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25941872594489303IS600 orfAQuickGO ontologyBLASTP
25946302595343714IS600 orfBQuickGO ontologyBLASTP
25968732597064192hypothetical proteinBLASTP
25973752597893519putative outer membrane lipoproteinQuickGO ontologyBLASTP
25979092598448540hypothetical proteinBLASTP
25988502599665816dihydropteroate synthaseQuickGO ontologyBLASTP
25997522600054303phosphoglucosamine mutaseQuickGO ontologyBLASTP
260023026017231494putative transposaseQuickGO ontologyBLASTP
26019342602158225hypothetical proteinBLASTP
26021552602892738resolvaseQuickGO ontologyBLASTP
26030402603372333putative transcriptional regulatorQuickGO ontologyBLASTP
26033692604136768putative arsenical resistance proteinQuickGO ontologyBLASTP
26041332604639507hypothetical arsenate reductaseQuickGO ontologyBLASTP
260463626057031068putative sodium bile acid symporter family proteinQuickGO ontologyBLASTP
26065992607087489hypothetical proteinBLASTP
26072372608043807putative mating pair formation proteinQuickGO ontologyBLASTP
26082822609061780putative mating pair formation proteinQuickGO ontologyBLASTP
26092022609390189putative stabilization proteinQuickGO ontologyBLASTP
26104232611304882putative replication protein CQuickGO ontologyBLASTP
26112912612118828putative DNA helicaseQuickGO ontologyBLASTP
26121232612344222hypothetical bacteriophage proteinQuickGO ontologyBLASTP
261249226136941203putative integraseQuickGO ontologyBLASTP
261399926155761578bifunctional GMP synthaseglutamine amidotransferase proteinQuickGO ontologyBLASTP