Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:4160500 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
416058341617821200hypothetical proteinBLASTP
41623114162586276IS1 orfAQuickGO ontologyBLASTP
41625054163008504IS1 orfBQuickGO ontologyBLASTP
41630194163318300IS600 orfAQuickGO ontologyBLASTP
416358341646081026hypothetical proteinBLASTP
41660114166571561possible chaperoneQuickGO ontologyBLASTP
416661541676941080probable fimbrial protein remnantQuickGO ontologyBLASTP
41679494168833885insertion sequence 2 OrfB proteinQuickGO ontologyBLASTP
41688124169222411insertion sequence 2 OrfA proteinQuickGO ontologyBLASTP
41705564171068513hypothetical proteinBLASTP
41711754171936762hypothetical proteinBLASTP
41721824172946765hypothetical proteinBLASTP
41729004173415516hypothetical proteinBLASTP
417676941783911623hypothetical proteinBLASTP
417875741798241068hypothetical proteinBLASTP
417982141825562736putative ATP-binding component of a transport systemQuickGO ontologyBLASTP
418255641836801125putative transporterQuickGO ontologyBLASTP
41840114184370360hypothetical proteinBLASTP
41844904184891402nickel responsive regulatorQuickGO ontologyBLASTP
41848974185703807ATP-binding protein of nickel transport systemQuickGO ontologyBLASTP
41857004186464765ATP-binding protein of nickel transport systemQuickGO ontologyBLASTP
41864644187297834transport of nickel membrane proteinQuickGO ontologyBLASTP
41872944188238945transport of nickel membrane proteinQuickGO ontologyBLASTP
418823841898121575periplasmic binding protein for nickelQuickGO ontologyBLASTP