Pre_GI Gene

Some Help

Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:1823000 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18230361823689654formate dehydrogenase-N nitrate-inducible cytochrome B556Fdn gamma subunitQuickGO ontologyBLASTP
18236821824566885formate dehydrogenase-N nitrate-inducible iron-sulfur beta subunitQuickGO ontologyBLASTP
182457918276263048formate dehydrogenase-N nitrate-inducible alpha subunitQuickGO ontologyBLASTP
18278581828739882hypothetical proteinBLASTP
182899418300941101putative outer membrane porin proteinQuickGO ontologyBLASTP
18308531831842990putative glycoproteinQuickGO ontologyBLASTP
18321301832405276IS1 orfAQuickGO ontologyBLASTP
18323241832827504IS1 orfBQuickGO ontologyBLASTP
183328518346731389nitrite extrusion protein 2QuickGO ontologyBLASTP
183982318410431221IS91 orfQuickGO ontologyBLASTP