Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:2741971 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27425502743233684putative transport proteinQuickGO ontologyBLASTP
27432882743881594heat shock protein GrpEQuickGO ontologyBLASTP
27440042744882879inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
274496827466291662DNA repair protein RecNQuickGO ontologyBLASTP
27469672747119153small membrane protein AQuickGO ontologyBLASTP
27471812747471291hypothetical proteinBLASTP
27474612747898438hypothetical proteinBLASTP
27480692748551483SsrA-binding proteinQuickGO ontologyBLASTP
2748766274912836310Sa RNA tmRNAQuickGO ontologyBLASTP
274933327505741242putative CP4-57-type integraseQuickGO ontologyBLASTP
27507742751073300IS1 orfAQuickGO ontologyBLASTP
27515892751888300IS3 orfAQuickGO ontologyBLASTP
27518852752313429IS3 orfBQuickGO ontologyBLASTP
27523332752440108IS3 orfBQuickGO ontologyBLASTP
2753003275307876tRNA-IleQuickGO ontologyBLASTP
27530412753214174hypothetical protein
27556172755889273hypothetical proteinBLASTP
275612027571571038hypothetical proteinBLASTP
275711127584451335hypothetical proteinBLASTP
2760083276121011284-aminobutyrate aminotransferaseQuickGO ontologyBLASTP
276144827628481401transport permease protein of gamma-aminobutyrateQuickGO ontologyBLASTP
27628692763531663putative transcriptional regulatorQuickGO ontologyBLASTP
27635322763981450hypothetical proteinBLASTP
27640652764223159hypothetical proteinBLASTP