Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:4132056 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
413205641333841329IS4 orfQuickGO ontologyBLASTP
413352941351781650cytoplasmic trehalaseQuickGO ontologyBLASTP
41354494135724276IS1 orfAQuickGO ontologyBLASTP
41356434136146504IS1 orfBQuickGO ontologyBLASTP
41378984138425528hypothetical proteinBLASTP
41392244139796573hypothetical proteinBLASTP
41400514140383333hypothetical proteinBLASTP
41404874140825339hypothetical proteinBLASTP
41415774142107531hypothetical proteinBLASTP
41422634142862600outer membrane protein induced after carbon starvationQuickGO ontologyBLASTP
41448804145836957hypothetical proteinBLASTP
41458674146370504IS1 orfBQuickGO ontologyBLASTP
41462894146564276IS1 orfAQuickGO ontologyBLASTP
41466204146964345transcriptional repressor of chromosomal ars operonQuickGO ontologyBLASTP
414701841483071290arsenical pump membrane proteinQuickGO ontologyBLASTP
41483204148745426arsenate reductaseQuickGO ontologyBLASTP
41489014149176276IS1 orfBQuickGO ontologyBLASTP
41490954149598504IS1 orfBQuickGO ontologyBLASTP
415051141518631353glutathione reductaseQuickGO ontologyBLASTP
41519354152777843hypothetical proteinBLASTP
415298041550222043oligopeptidase AQuickGO ontologyBLASTP
41550304155782753hypothetical proteinBLASTP