Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:4364235 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
436423543655781344gluconate transport system permease 3QuickGO ontologyBLASTP
43658294366731903minor fimbrial subunit D-mannose specific adhesinQuickGO ontologyBLASTP
43667514367254504minor fimbrial subunit precursor polypeptideQuickGO ontologyBLASTP
43672674367797531minor fimbrial subunit precursor polypeptideQuickGO ontologyBLASTP
43698714370374504IS1 orfBQuickGO ontologyBLASTP
43702934370568276IS1 orfAQuickGO ontologyBLASTP
43712864372011726periplasmic chaperoneQuickGO ontologyBLASTP
43720484372686639fimbrial proteinQuickGO ontologyBLASTP
43726524373200549major type 1 subunit fimbrin pilinQuickGO ontologyBLASTP
43736814374277597recombinase regulator for fimAQuickGO ontologyBLASTP
43748724375357486recombinase regulator for fimAQuickGO ontologyBLASTP
43769794377527549hypothetical proteinBLASTP
437743943786531215hypothetical proteinBLASTP
43789404379698759hypothetical proteinBLASTP
43801674380670504IS1 orfBQuickGO ontologyBLASTP
43805894380864276IS1 orfAQuickGO ontologyBLASTP
43809594381654696putative deoR family transcriptional regulatorQuickGO ontologyBLASTP
43817554381871117hypothetical proteinBLASTP
43821304382408279ISEhe3a orfQuickGO ontologyBLASTP
43824774382779303IS600 orfAQuickGO ontologyBLASTP
43829204383633714IS600 orfBQuickGO ontologyBLASTP
43849014385176276IS1 orfAQuickGO ontologyBLASTP
43850954385598504IS1 orfBQuickGO ontologyBLASTP
43857914386093303IS911 orfAQuickGO ontologyBLASTP
43863334386959627IS911 orfBQuickGO ontologyBLASTP
438693443881451212putative P4-type integraseQuickGO ontologyBLASTP
4388344438842885tRNA-LeuQuickGO ontologyBLASTP
438858243896431062putative oxidoreductaseQuickGO ontologyBLASTP