Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:2169877 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21698772170698822hypothetical proteinBLASTP
21707632171563801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
21715602172348789hydroxyethylthiazole kinaseQuickGO ontologyBLASTP
21725712172843273hypothetical proteinBLASTP
217548321779632481putative outer membrane proteinQuickGO ontologyBLASTP
21787342179258525putative fimbrial-like proteinQuickGO ontologyBLASTP
21795342180037504IS1 orfBQuickGO ontologyBLASTP
21799562180231276IS1 orfAQuickGO ontologyBLASTP
21803282180609282hypothetical proteinBLASTP
218087121819801110putative ATPaseQuickGO ontologyBLASTP
218211221841452034methionyl-tRNA synthetaseQuickGO ontologyBLASTP