Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:3240909 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
324090932422731365putative L-serine deaminaseQuickGO ontologyBLASTP
32423453242734390hypothetical proteinBLASTP
324274832450422295probable formate acetyltransferase 3QuickGO ontologyBLASTP
324507632462841209acetatepropionate kinaseQuickGO ontologyBLASTP
324631032476411332anaerobically inducible permease for L-threonine and L-serineQuickGO ontologyBLASTP
32476633248652990threonine dehydrataseQuickGO ontologyBLASTP
32487513249689939transcriptional activator of tdc operonQuickGO ontologyBLASTP
32498793250223345threonine dehydratase operon activator proteinQuickGO ontologyBLASTP
32522753252439165hypothetical proteinBLASTP
32528283253204377RNA component of RNase PQuickGO ontologyBLASTP
325323732544631227hypothetical proteinBLASTP
32544793255378900putative dehydrogenaseQuickGO ontologyBLASTP
325618532575191335putative transport proteinQuickGO ontologyBLASTP
325789432594651572putative hydrolaseQuickGO ontologyBLASTP
32595173260341825putative DEOR-type transcriptional regulator of aga operonQuickGO ontologyBLASTP
326059032618701281putative tagatose 6-phosphate kinase 2QuickGO ontologyBLASTP
32618573262366510cytoplasmic transport protein N-acetylgalactosamine-specific IIB component 2 EIIB-AGAQuickGO ontologyBLASTP