Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:310382 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
310382310657276IS1 orfAQuickGO ontologyBLASTP
310576311079504IS1 orfBQuickGO ontologyBLASTP
3112703123731104gamma-glutamyl kinaseQuickGO ontologyBLASTP
3123853136381254gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
31375331382876tRNA-ThrQuickGO ontologyBLASTP
3138433150061164putative phage integraseQuickGO ontologyBLASTP
315192315494303IS600 orfAQuickGO ontologyBLASTP
315635316348714IS600 orfBQuickGO ontologyBLASTP
316401317051651hypothetical bacteriophage proteinQuickGO ontologyBLASTP
316960317421462putative phage tail fibre proteinQuickGO ontologyBLASTP
3182293192781050hypothetical proteinBLASTP
3197293209191191hypothetical proteinBLASTP
3213093227691461putative glucosyl tranferase IIQuickGO ontologyBLASTP
322766323695930putative bactoprenol glucosyl transferaseQuickGO ontologyBLASTP
323692324054363putative flippaseQuickGO ontologyBLASTP
324316324609294integrase fragmentQuickGO ontologyBLASTP
324718325431714IS600 orfBQuickGO ontologyBLASTP
325572325874303IS600 orfAQuickGO ontologyBLASTP
3260603272231164putative phage integraseQuickGO ontologyBLASTP
3275723287441173hypothetical proteinBLASTP
329548329988441IS600 orfBQuickGO ontologyBLASTP
330729331349621IS629 orfBQuickGO ontologyBLASTP
331711331929219IS629 orfAQuickGO ontologyBLASTP
3320803331951116hypothetical proteinBLASTP
333212334021810pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
334021334599579hypothetical proteinBLASTP
334782335306525shikimate kinase IIQuickGO ontologyBLASTP
335356335547192hypothetical proteinBLASTP
335805336482678protein of aro operonQuickGO ontologyBLASTP
336554336838285hypothetical proteinBLASTP
337047337328282hypothetical proteinBLASTP
337325337780456hypothetical proteinBLASTP