Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:366822 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
36682236868418631-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
368709369608900geranyltranstransferase farnesyldiphosphate synthaseQuickGO ontologyBLASTP
369608369850243exodeoxyribonuclease VII small subunitQuickGO ontologyBLASTP
3700563715041449thiamine biosynthesis protein ThiIQuickGO ontologyBLASTP
3715583721545974-methyl-5b-hydroxyethyl-thiazole monophosphate biosynthesis ThiJ proteinQuickGO ontologyBLASTP
3721113730229122-dehydropantoate 2-reductaseQuickGO ontologyBLASTP
373190373681492hypothetical proteinBLASTP
3737413754711731hypothetical proteinBLASTP
3755243776772154hypothetical proteinBLASTP
377828378103276IS1 orfAQuickGO ontologyBLASTP
378231378524294IS1 orfBQuickGO ontologyBLASTP
378572378811240hypothetical proteinBLASTP
379105379416312hypothetical proteinBLASTP
379600380487888protoheme IX farnesyltransferaseQuickGO ontologyBLASTP
380502380831330cytochrome o ubiquinol oxidase subunit IVQuickGO ontologyBLASTP
380831381445615cytochrome o ubiquinol oxidase subunit IIIQuickGO ontologyBLASTP
3839783850271050ISSfl3 orfDQuickGO ontologyBLASTP
385243385431189ISSfl3 orfCQuickGO ontologyBLASTP
385428385562135ISSfl3 orfCQuickGO ontologyBLASTP
385582385929348ISSfl3 orfBQuickGO ontologyBLASTP
385926386423498ISSfl3 orfAQuickGO ontologyBLASTP
3869703884451476beta-lactamase induction signal transducer AmpGQuickGO ontologyBLASTP
388489389169681putative polymeraseproteinaseQuickGO ontologyBLASTP
389339389689351possible regulator of murein genesQuickGO ontologyBLASTP