Pre_GI Gene

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Host: NC_004741 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004741:1792442 Shigella flexneri 2a str. 2457T, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
179244217936021161putative amino acidamine transport proteinQuickGO ontologyBLASTP
17936141794480867shikimate 5-dehydrogenaseQuickGO ontologyBLASTP
179451117952697593-dehydroquinate dehydrataseQuickGO ontologyBLASTP
17953511795854504IS1 orfBQuickGO ontologyBLASTP
17957731796048276IS1 orfAQuickGO ontologyBLASTP
179770117988581158putative enzymeQuickGO ontologyBLASTP
180087218032322361hypothetical proteinBLASTP
18035021804005504IS1 orfBQuickGO ontologyBLASTP
18039241804199276IS1 orfAQuickGO ontologyBLASTP
18068101807085276IS1 orfAQuickGO ontologyBLASTP
18070041807507504IS1 orfBQuickGO ontologyBLASTP
180798518093851401glutamate decarboxylase isozymeQuickGO ontologyBLASTP
180954118110761536acid sensitivity protein putative transporterQuickGO ontologyBLASTP