Pre_GI Gene

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Host: NC_000921 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000921:1007519 Helicobacter pylori J99, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
100751910089821464hypothetical proteinBLASTP
100899810104791482septum formation proteinQuickGO ontologyBLASTP
101060710117641158cell division protein FtsZQuickGO ontologyBLASTP
101209010133251236hypothetical proteinBLASTP
10136721014496825hypothetical proteinBLASTP
10146361014830195hypothetical proteinBLASTP
101504210164691428DNA transfer proteinQuickGO ontologyBLASTP
10164571016879423DNA transfer proteinQuickGO ontologyBLASTP
101691610181931278topoisomerase IQuickGO ontologyBLASTP
10185681018849282hypothetical proteinBLASTP
10189791019965987hypothetical proteinBLASTP
10214981022304807hypothetical proteinBLASTP
10219621022549588hypothetical proteinBLASTP
102255610235721017hypothetical proteinBLASTP
102377710251741398hypothetical proteinBLASTP
102532410320196696hypothetical proteinBLASTP
10320251032477453hypothetical proteinBLASTP
10325911032833243hypothetical proteinBLASTP
103284610349062061topoisomerase IQuickGO ontologyBLASTP
10349611035431471hypothetical proteinBLASTP
10354011036204804hypothetical proteinBLASTP
103627710372961020hypothetical proteinBLASTP
10373431037885543hypothetical proteinBLASTP
10380831038616534hypothetical proteinBLASTP
103861310398781266hypothetical proteinBLASTP
103989010411401251hypothetical proteinBLASTP
104114510421581014hypothetical proteinBLASTP
10423901043367978hypothetical proteinBLASTP
104577810478112034hypothetical proteinBLASTP
10483761048561186hypothetical proteinBLASTP
10491071049874768hypothetical proteinBLASTP
104987410518802007hypothetical proteinBLASTP
10516731052110438hypothetical proteinBLASTP
105213710535371401hypothetical proteinBLASTP
10535881053866279hypothetical proteinBLASTP
105386810551301263hypothetical proteinBLASTP
10552021055885684hypothetical proteinBLASTP