Some Help

Query: NC_000921:1007519:1051673 Helicobacter pylori J99, complete genome

Start: 1051673, End: 1052110, Length: 438

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1030148:1062302106230210644732172Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein6e-29125
NC_011333:1040192:1078838107883810810512214Helicobacter pylori G27 chromosome, complete genomeperiplasmic competence protein-like protein2e-28124
NC_017367:278916:3174963174963196132118Helicobacter pylori F57, complete genomehypothetical protein7e-27119
NC_014560:1366747:1377248137724813794582211Helicobacter pylori SJM180 chromosome, complete genomeperiplasmic competence protein-like protein8e-27119
NC_017375:1498000:151758415175841518234651Helicobacter pylori 83 chromosome, complete genomehypothetical protein2e-26117
NC_017361:1528239:1561161156116115633562196Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein5e-26116
NC_017361:930280:9385279385279407222196Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein5e-26116
NC_010698:870312:8787308787308808712142Helicobacter pylori Shi470, complete genomehypothetical protein4e-26116
NC_017358:220900:2603022603022624942193Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein7e-24108
NC_011498:448000:457332457332457577246Helicobacter pylori P12, complete genomehypothetical protein8e-0855.8