Pre_GI Gene

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Host: NC_017367 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017367:278916 Helicobacter pylori F57, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2789162801511236adenylosuccinate synthetaseQuickGO ontologyBLASTP
280148280576429hypothetical proteinBLASTP
280569281228660hypothetical proteinBLASTP
2812252822801056hypothetical proteinBLASTP
2822932835551263exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
283574284185612Type II DNA modification enzymeQuickGO ontologyBLASTP
284353285117765hypothetical proteinBLASTP
2851282870441917hypothetical proteinBLASTP
287034287336303virB2 type IV secretion proteinQuickGO ontologyBLASTP
287337287597261virB3 type IV secretion proteinQuickGO ontologyBLASTP
2876102901082499DNA transfer proteinQuickGO ontologyBLASTP
2900922920351944topoisomerase IQuickGO ontologyBLASTP
292035292166132hypothetical proteinBLASTP
292168293154987hypothetical proteinBLASTP
2931542946951542Component of conjugal plasmid transfer systemQuickGO ontologyBLASTP
2946922959271236ComB3 proteinQuickGO ontologyBLASTP
296024296290267hypothetical proteinBLASTP
296283296546264hypothetical proteinBLASTP
296543296695153hypothetical protein
296841297782942VIRB11QuickGO ontologyBLASTP
297779298234456hypothetical proteinBLASTP
298231298521291hypothetical proteinBLASTP
298522299079558hypothetical proteinBLASTP
2990803008371758conjugal transfer proteinQuickGO ontologyBLASTP
301112301393282hypothetical proteinBLASTP
301386301700315hypothetical proteinBLASTP
3019963039061911hypothetical proteinBLASTP
3039313050941164hypothetical proteinBLASTP
305126305395270hypothetical proteinBLASTP
305477306133657PARA proteinQuickGO ontologyBLASTP
3063993148558457hypothetical proteinBLASTP
3150093160461038hypothetical proteinBLASTP
316047316295249hypothetical proteinBLASTP
316589317041453hypothetical proteinBLASTP
317023317439417hypothetical proteinBLASTP
3174963196132118hypothetical proteinBLASTP