Pre_GI Gene

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Host: NC_011333 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011333:1040192 Helicobacter pylori G27 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori is a gram-negative pathogen that colonizes the stomachs of over half the world's population. Originally isolated from an endoscopy patient from Grosseto Hospital (Tuscany, Italy). Causes peptic ulcers. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
104019210421441953methionyl-tRNA synthetaseQuickGO ontologyBLASTP
104231310434821170cyclopropane fatty acid synthaseQuickGO ontologyBLASTP
104349210453751884hypothetical proteinBLASTP
10457641046528765hypothetical proteinBLASTP
104654010482161677hypothetical proteinBLASTP
10484321048734303hypothetical proteinBLASTP
10487351048995261hypothetical proteinBLASTP
105162310534341812DNA topoisomerase IQuickGO ontologyBLASTP
10535641054550987competence proteinQuickGO ontologyBLASTP
105455010560911542comB9-like competence proteinQuickGO ontologyBLASTP
105608810573231236competence proteinQuickGO ontologyBLASTP
10573931057689297hypothetical proteinBLASTP
10579391058205267hypothetical proteinBLASTP
10582371059178942virB11-like type IV secretion system ATPaseQuickGO ontologyBLASTP
10591751059630456hypothetical proteinBLASTP
10596271059917291hypothetical proteinBLASTP
10599181060475558hypothetical proteinBLASTP
106047610622031728cag island DNA transfer proteinQuickGO ontologyBLASTP
10627401063054315hypothetical proteinBLASTP
106333610652461911hypothetical proteinBLASTP
106527110664431173hypothetical proteinBLASTP
10664751066759285hypothetical proteinBLASTP
10668421067498657PARA proteinQuickGO ontologyBLASTP
106776410761908427adenine specific DNA methyltransferaseQuickGO ontologyBLASTP
107634510773821038hypothetical proteinBLASTP
107738310787771395hypothetical proteinBLASTP
107883810810512214periplasmic competence protein-like proteinQuickGO ontologyBLASTP
108105510824401386hypothetical proteinBLASTP
108244010836421203hypothetical proteinBLASTP