Pre_GI Gene

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Host: NC_017375 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017375:1498000 Helicobacter pylori 83 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
149818715019603774type II restriction-modification enzymeQuickGO ontologyBLASTP
15020861502544459hypothetical proteinBLASTP
150251915036851167hypothetical proteinBLASTP
15037171504001285hypothetical proteinBLASTP
15040861504448363PARA proteinQuickGO ontologyBLASTP
15044451504741297PARA proteinQuickGO ontologyBLASTP
150499415134118418DNA methylaseQuickGO ontologyBLASTP
151356615146031038hypothetical proteinBLASTP
151460415159981395hypothetical proteinBLASTP
151604215175441503hypothetical proteinBLASTP
15175841518234651hypothetical proteinBLASTP
151823815196231386hypothetical proteinBLASTP
151962315208251203hypothetical proteinBLASTP
152088715219631077integraserecombinaseQuickGO ontologyBLASTP